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A proof that is working in you right now

The Cell Is a Factory

Your body has thirty trillion cells. Each one has a design office, machine tools, an assembly line, a warehouse, loaders and a power plant with turbines.

Nobody who sees a factory thinks it appeared by itself. Let us go inside and see how it is built. Everything shown here has been measured in laboratories.

1 · Workshops

Walk through the factory

In front of you is a single cell, 0.02 mm across. Tap a workshop and it lights up.

The factory comparison was not invented by believers. This is how biology textbooks and biologists themselves describe the cell.

2 · Transport

A loader on two legs

This is kinesin, a protein motor. It walks along a protein rail and drags a vesicle with cargo hundreds of times bigger than itself. It moves its legs one after the other, like a person.

8 nmstep length
~100steps per second
1 ATPof fuel per step

The vesicle carries an address tag, and the loader takes it where it needs to go. In a nerve cell this road can be up to a meter long: from the spine to the toes. On its own, the cargo would take years to get there.

Green flash: one ATP molecule has burned. Slowed down about 60 times on screen.

3 · Power plant

A dam five nanometers thick

People get energy from fire, dams and nuclear decay. But in the end it is almost always the same thing: something has to turn a turbine. Your cells have turbines too. Only they are turned not by steam or water, but by a flow of protons.

This is the mitochondrial membrane. On the left are three pumps: they burn fuel from food and pump protons (red dots) upward. More and more of them pile up at the top, like water behind a dam. They can only get back through the turbine on the right.

0.15 Vvoltage across the membrane
30 million V/mfield strength. Air breaks down with a spark at 3 million

Peter Mitchell received the Nobel Prize in 1978 for discovering this principle. He called it the “proton motive force”.

4 · Turbine

The proton engine

ATP synthase. Protons settle on the golden ring of the rotor and turn it. The rotor spins a bent shaft, the shaft squeezes three chambers below one after another, and out of each comes a charged battery: an ATP molecule (green).

Proton pressure
pumps stopped×1,5

The turbine is about 10 nm across: several thousand of them would fit side by side across the width of a hair. The rotor, stator, shaft and three chambers are assembled from about thirty protein parts. The design was worked out by Boyer and Walker, Nobel Prize 1997. Slowed down 200 times on screen.

5 · Numbers

What our factories cannot do

≈ body weightthis much ATP your turbines make in a day: tens of kilograms. Each battery is recharged more than a thousand times a day
almost 100%efficiency of the ATP synthase motor as measured. A nuclear plant is about 33%, a car engine 25–40%
thousands of timesmore energy per kilogram is produced by your body than by the Sun: about 1 W versus 0.0002 W
1 in a billionerrors when copying DNA after all the checks. The machine, the copier and the inspector work together
10 millionribosome machines in a single human cell. Each builds a protein from a program, part by part
20 minutesis what a bacterium needs to build a full copy of the entire factory, machines and blueprints included
recyclingbroken parts are taken apart for spares and put back to use
0.02 mmthe size of the whole factory. A power plant, an assembly line, a warehouse and transport inside a speck of dust

Humanity has mastered electric current and the nuclear reactor. But a ten-nanometer proton turbine that assembles, repairs and copies itself is something we cannot reproduce. We are only learning to understand it.

6 · A closed circle

To build a power plant, you need electricity

The turbine is made of proteins
↓
Proteins are built by ribosome machines, and they need ATP energy
↓
ATP is made by the turbine
↓
The blueprints of the turbine and the machines are stored in DNA, and only proteins can read and copy DNA, which also takes ATP

No link works without the rest. The factory must appear all at once and complete: with blueprints, machines, energy and a wall around it.

In 2016 a laboratory built the simplest cell it could: 473 genes. Remove one more, and it cannot live. At that time nobody knew what a third of those genes were for.

Hutchison et al., Science, 2016 (the JCVI-syn3.0 cell).

7 · What biologists themselves say

This is not what theologians say

“The entire cell can be viewed as a factory that contains an elaborate network of interlocking assembly lines, each of which is composed of a set of large protein machines.”

Bruce Alberts, President of the US National Academy of Sciences. Cell journal, 1998

“We must concede that there are presently no detailed Darwinian accounts of the evolution of any biochemical or cellular system, only a variety of wishful speculations.”

Franklin Harold, biochemist and supporter of evolution. The Way of the Cell, 2001
“Selection gradually created all this”

Selection works only where something already reproduces. And only a whole factory reproduces: blueprints, machines, energy, a wall. Selection does not explain the appearance of what it needs in order to start at all.

“The turbine was assembled from parts that had other jobs”

The parts of a washing machine look like parts of other machines. But an engineer assembles a machine from them. The ring, shaft and chambers must fit each other to a fraction of a nanometer, or the rotor will not turn.

“It is just chemistry”

A nuclear plant is also just physics. The question is not what it is made of, but who arranged the parts so that it works.

Conclusion
A factory has→a builder
A nuclear plant has→engineers
A living cell has→
What next

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